IntroductionThe therapeutic potential of bispecific antibodies is becoming widely recognised, with over a hundred formats already described.For many applications, enhanced tissue penetration is sought, so bispecifics with low molecular weight may offer a route to enhanced potency.Here we report the design of bi- and tri-specific antibody-based cons
Abstract Background Dislodgement of a coronary stent-balloon catheter during percutaneous coronary intervention (PCI) is rare but is a life-threatening complication.Case summary A 57- year-old male presented with a non-ST elevation myocardial infarction (NSTEMI).Coronary angiography revealed apunisw2 total thrombotic occlusion of the Right coronary
MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities.One major here function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation.This function is in turn controlled by the cell fate determinant NUMB, which binds to and inhibits MDM2 via a shor